Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits

Citation
Y. Hyun et al., Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits, ONCOL REP, 8(6), 2001, pp. 1309-1311
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
6
Year of publication
2001
Pages
1309 - 1311
Database
ISI
SICI code
1021-335X(200111/12)8:6<1309:PDTBFL>2.0.ZU;2-T
Abstract
We previously reported the continuous decrease of total body fat in VX2-car cinoma-bearing rabbits after tumor implantation, as well as changes in the serum lipid profile. Probucol, an antioxidant drug, has a cholesterol lower ing effect against hyperlipidemic subjects. VX2-carcinoma-bearing rabbits f ed with a diet containing 1% probucol did not show any difference in serum lipid compositions as compared with rabbits fed with a control diet. Simila rly serum lipolytic activity showed no differences, whether probucol was ad ministered or not, while the decrease in total body fat was significantly l ess when probucol was administered.