We previously reported the continuous decrease of total body fat in VX2-car
cinoma-bearing rabbits after tumor implantation, as well as changes in the
serum lipid profile. Probucol, an antioxidant drug, has a cholesterol lower
ing effect against hyperlipidemic subjects. VX2-carcinoma-bearing rabbits f
ed with a diet containing 1% probucol did not show any difference in serum
lipid compositions as compared with rabbits fed with a control diet. Simila
rly serum lipolytic activity showed no differences, whether probucol was ad
ministered or not, while the decrease in total body fat was significantly l
ess when probucol was administered.