TT dinucleotides containing an isoxazoline moiety: Synthesis and binding affinity study

Citation
Jr. Kong et al., TT dinucleotides containing an isoxazoline moiety: Synthesis and binding affinity study, NUCLEOS NUC, 20(10-11), 2001, pp. 1751-1760
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
1525-7770 → ACNP
Volume
20
Issue
10-11
Year of publication
2001
Pages
1751 - 1760
Database
ISI
SICI code
1525-7770(2001)20:10-11<1751:TDCAIM>2.0.ZU;2-Z
Abstract
We have prepared four diastereomers of TT dinucleotides containing an isoxa zoline moiety and four dodecanucleotides incorporating these TT dinucleotid es in the middle of the DNA sequence. We also have determined the melting t emperatures of these modified oligonucleotides (Tin values) by measuring ch ange in UV absorbance.