Age-dependent impairment of delay and trace eyeblink conditioning in mice

Citation
Y. Kishimoto et al., Age-dependent impairment of delay and trace eyeblink conditioning in mice, NEUROREPORT, 12(15), 2001, pp. 3349-3352
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
12
Issue
15
Year of publication
2001
Pages
3349 - 3352
Database
ISI
SICI code
0959-4965(20011029)12:15<3349:AIODAT>2.0.ZU;2-H
Abstract
The age effect on classical eyeblink conditioning in unrestrained mice (C57 BL/6J strain) was evaluated. Mice were trained at one of three age periods (8, 45-50 or 85-90 weeks). In the delay paradigm, significant learning defi cits were evident in the 85-90 week-old group, but no deficits were observe d in the behavior of the 45-50 week-old group. On the other hand, in the tr ace paradigm with a stimulus-free trace interval of 500 ms, significant def icits became apparent at the age of 45-50 weeks. These results indicate tha t trace eyeblink conditioning is more susceptible to age-related deteriorat ion of memory in mice than delay eyeblink conditioning. NeuroReport 12:3349 -3352 (C) 2001 Lippincott Williams & Wilkins.