Bone and soft tissue regeneration by bone marrow mesenchymal cells

Citation
T. Yoshikawa et al., Bone and soft tissue regeneration by bone marrow mesenchymal cells, MAT SCI E C, 17(1-2), 2001, pp. 19-26
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Apllied Physucs/Condensed Matter/Materiales Science
Journal title
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
ISSN journal
0928-4931 → ACNP
Volume
17
Issue
1-2
Year of publication
2001
Pages
19 - 26
Database
ISI
SICI code
0928-4931(20011101)17:1-2<19:BASTRB>2.0.ZU;2-T
Abstract
Culture of bone marrow blood produces bone marrow mesenchymal cells that ad here to the bottom of the culture dish. These cells are known to include ce lls that can differentiate in various directions. Culturing these marrow me senchymal cells with differentiation factors and biomaterials can achieve r egeneration of bone and soft tissue. The present study showed that culture of marrow mesenchymal cells with porous artificial bone material in an oste ogenic culture medium containing dexamethasone could produce new bone tissu e on the artificial material. This bio-artificial bone graft substitute cou ld effectively regenerate bone tissue when it was implanted in vivo. Porous artificial bone material treated with a small amount of bone morphogenetic protein (BMP) and perfused with marrow mesenchymal cells also markedly sti mulated bone regeneration by the interaction between the cells and BMP. Sim ilarly, when an artificial dermis made of collagen sponge was perfused with marrow mesenchymal cells and used to cover a skin defect, the regeneration of blood vessels was stimulated. Since the present results demonstrated th e ability of marrow mesenchymal cells to regenerate bone and soft tissue, t hese cells are expected to be useful for tissue regeneration therapy. (C) 2 001 Elsevier Science B.V. All rights reserved.