New cytotoxic sesterterpenes from the sponge Sarcotragus species

Citation
Yh. Liu et al., New cytotoxic sesterterpenes from the sponge Sarcotragus species, J NAT PROD, 64(10), 2001, pp. 1301-1304
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
10
Year of publication
2001
Pages
1301 - 1304
Database
ISI
SICI code
0163-3864(200110)64:10<1301:NCSFTS>2.0.ZU;2-L
Abstract
Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine sponge Sarcotragus sp. by bioactivity-g uided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations o f geometry and absolute configuration.