Dietary fibres and ovarian cancer risk

Citation
C. Pelucchi et al., Dietary fibres and ovarian cancer risk, EUR J CANC, 37(17), 2001, pp. 2235-2239
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
EUROPEAN JOURNAL OF CANCER
ISSN journal
0959-8049 → ACNP
Volume
37
Issue
17
Year of publication
2001
Pages
2235 - 2239
Database
ISI
SICI code
0959-8049(200111)37:17<2235:DFAOCR>2.0.ZU;2-R
Abstract
Data from an Italian multicentre case-control study on ovarian cancer were used to analyse the relationship between various types of fibres and ovaria n cancer risk. The study, conducted between 1992 and 1999, included 1031 ca ses of incident, histologically-confirmed epithelial ovarian cancer. Contro ls were 2411 women admitted to the same network of hospitals for acute, non -malignant, non-hormonal-related diseases. Cases and controls were intervie wed using a validated food frequency questionnaire (FFQ). Odds ratios (ORs) , and the corresponding 95% confidence intervals (CI), were estimated using unconditional multiple logistic regression models. For total (Englyst) fib re, the OR for the highest versus the lowest quintile of intake was 0.68, a nd the continuous OR for the difference between the 80th and the 20th perce ntile of intake was 0.87. For most types of fibre, the continuous OR was si gnificantly below 1. The OR was 0.83 for cellulose, 0.89 for soluble non-ce llulose polysaccharides (NCPs), 0.86 for total insoluble fibre, 0.92 for in soluble NCP, and 0.95 (non-significant) for lignin. The inverse association was consistent across strata of age, family history and menopausal status, even if the association was apparently stronger in postmenopausal women. W hen fibre was lassified according to the source, vegetable (but not grain) fibres, showed a significant protective effect, with an OR of 0.78. (C) 200 1 Elsevier Science Ltd. All rights reserved.