Overexpression of the A(1) adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance

Dong, Q Ginsberg, HN Erlanger, BF

Q. Dong et al., Overexpression of the A(1) adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance, DIABET OB M, 3(5), 2001, pp. 360-366

24

INGLESE

Article

Endocrynology, Metabolism & Nutrition

DIABETES OBESITY & METABOLISM

1462-8902 → ACNP

3

5

2001

360 - 366

ISI

1462-8902(200110)3:5<360:OOTAAR>2.0.ZU;2-A

In-vitro studies have implicated the A, adenosine receptor (A(1)AR) of adip ocytes in inhibition of lipolysis, stimulation of lipogenesis and enhanceme nt of the action of insulin on glucose metabolism. To determine whether any of these activities were physiologically relevant in an intact animal, A(1 )AR was overexpressed in adipose tissue of transgenic mice. Lower plasma fr ee fatty acid (FFA) levels were observed in the transgenic mice relative to the litter-matched controls. supporting a significant physiological role f or adipocyte A(1)AR in the control of lipolysis. However, no differences we re observed in body weights or body composition. On a high fat diet, both t he transgenic mice and the litter matched controls, male and female, became equally obese. Unlike the control mice, however, the transgenic mice did n ot develop insulin resistance, as demonstrated by serum glucose and insulin levels and glucose and insulin tolerance tests. These findings demonstrate that adipocyte A(1)AR plays an important physiological role in the control of insulin sensitivity in an intact animal and therefore should be conside red to be a potential therapeutic target for the treatment of obesity-relat ed insulin resistance and type 2 diabetes.