Ocular and systemic factors relevant to diabetic keratoepitheliopathy

Citation
K. Inoue et al., Ocular and systemic factors relevant to diabetic keratoepitheliopathy, CORNEA, 20(8), 2001, pp. 798-801
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Optalmology
Journal title
CORNEA
ISSN journal
0277-3740 → ACNP
Volume
20
Issue
8
Year of publication
2001
Pages
798 - 801
Database
ISI
SICI code
0277-3740(200111)20:8<798:OASFRT>2.0.ZU;2-U
Abstract
Purpose. This study examines the contribution of ocular and systemic factor s to diabetic keratoepitheliopathy. Methods. The presence and severity of k eratoepitheliopathy was investigated in 114 eves of patients with diabetes and 59 eyes of patients without diabetes. The ocular factors examined were the status of the lipid layer of the tear fluid assessed with the specular reflection videorecording system, corneal sensitivity using the Cochet-Bonn et method, tear volume by the cotton thread test, tear film stability by te ar break-up time, and grade of diabetic retinopathy. The systemic factors e xamined included patient age, hemoglobin Ale value, and duration of diabete s mellitus. Multivariate regression analysis was performed to assess the fa ctors related to keratoepitheliopathy. Results. The incidence of keratoepit heliopathy was 22.8% and 8.5% in patients with and without diabetes, respec tively. Ocular measures, such as nonuniformity of tear lipid layer, corneal sensitivity, and tear breakup time, were significantly worse in patients w ith diabetes than in patients without diabetes (p < 0.05). Multivariate reg ression analysis showed that the status of the tear lipid layer was signifi cantly relevant to diabetic keratoepitheliopathy (p < 0.05). Conclusion. Qu alitative abnormalities in tear secretion seem relevant to the development of diabetic keratoepitheliopathy. The tear lipid layer interference pattern may yield useful information for the elucidation of the mechanism and trea tment of diabetic keratoepitheliopathy.