Reference intervals and variation for urinary epinephrine, norepinephrine and cortisol in healthy men and women in Denmark

Citation
Am. Hansen et al., Reference intervals and variation for urinary epinephrine, norepinephrine and cortisol in healthy men and women in Denmark, CLIN CH L M, 39(9), 2001, pp. 842-849
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
ISSN journal
1434-6621 → ACNP
Volume
39
Issue
9
Year of publication
2001
Pages
842 - 849
Database
ISI
SICI code
1434-6621(200109)39:9<842:RIAVFU>2.0.ZU;2-6
Abstract
Reference intervals for urinary epinephrine, norepinephrine and cortisol in 120 healthy individuals performing their routine work were established acc ording to the International Union of Pure and Applied Chemistry (IUPAC) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) for use in the risk assessment of exposure to occupational stress. Reference intervals were established for three different times of the day: in morning samples (05.45-07.15) the limit of detection (LOD) was 2.10 mu m ol epinephrine/mol creatinine (82 women) and 2.86 mu mol epinephrine/mol cr eatinine (37 men), and the reference interval was 3.6-29.1 mu mol norepinep hrine/mol creatinine and 2.3-52.8 mu mol cortisol/mol creatinine (119 women and men); in afternoon samples (15.30-18.30) the reference interval was 0. 64-10.8 mu mol epinephrine/mol creatinine (82 women), 1.20-11.2 mu mol/epin ephrine/mol creatinine (36 men), 11.0-54.1 mu mol/norepinephrine/mol creati nine and LOD was 42.4 mu mol cortisol/mol creatinine (117 women and men); i n evening samples (21.45-23.45) LOD was 8.66 mu mol epinephrine/mol creatin ine (81 women) and 7.99 mu mol/epinephrine/mol creatinine (36 men), the ref erence interval was 11.0-54.1 mu mol norepinephrine/mol creatinine, and LOD was 42.4 pmol cortisol/mol creatinine (117 women and men). A variance comp onent model for describing the effects of age, body mass index (BMI), diurn al variation, gender, days of sick leave during past year and smoking habit s was established. Women showed a higher morning value but excreted lower a mounts of epinephrine during the day as compared to men. No gender differen ces could be demonstrated for the excretion of norepinephrine and cortisol. Excretion of epinephrine and norepinephrine increased with smoking and dec reased with increased BMI. No effects were observed in the excretion of cor tisol.