Hydrocarbon carcinogens induce p53 activity in normal mouse tissue

Citation
D. Stuart et al., Hydrocarbon carcinogens induce p53 activity in normal mouse tissue, CANCER LETT, 173(2), 2001, pp. 111-114
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
173
Issue
2
Year of publication
2001
Pages
111 - 114
Database
ISI
SICI code
0304-3835(20011128)173:2<111:HCIPAI>2.0.ZU;2-7
Abstract
Previous studies led to the suggestion that a sub class of hydrocarbon carc inogens have the capacity of damage DNA and evade normal cellular defence m echanisms. To examine the ability of hydrocarbon carcinogens to induce p53 transcriptional activity in normal tissues, we have used transgenic mice in which LacZ transgene is driven by a p53 response element. We demonstrate t hat transcriptionally active p53 is induced in normal tissue after exposure to putative stealth carcinogens in an identical manner to non-stealth agen ts. (C) 2001 Published by Elsevier Science Ireland Ltd.