Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China

Citation
M. Su et al., Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, WORLD J GAS, 7(5), 2001, pp. 657-661
Citations number
66
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
WORLD JOURNAL OF GASTROENTEROLOGY
ISSN journal
1007-9327 → ACNP
Volume
7
Issue
5
Year of publication
2001
Pages
657 - 661
Database
ISI
SICI code
1007-9327(200110)7:5<657:RBABGA>2.0.ZU;2-2
Abstract
AIM To study the relationship between ABO blood groups and carcinoma of eso phagus and cardia in Chaoshan inhabitants of China, which is a unique Litto ral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago. METHODS Data on age, sex, ABO blood type and X-ray or pathological diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital o f Shantou University Medical College; and the Central Hospital of Shantou a nd the Central Hospital of Jieyang. A total of 6 685 patients with esophage al carcinoma (EC) and 2 955 patients with cardiac cancer (CC) in Chaoshan d istrict were retrospectively assessed for their association with ABO blood groups. RESULTS The distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper th ird esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B: O was 1.1415 (P <0.05) and 1.2696 (P <0.05), respectively . No relationship was found between ABO blood groups and tumor differentiat ion. CONCLUSION ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distribution o f ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.