M. Su et al., Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, WORLD J GAS, 7(5), 2001, pp. 657-661
AIM To study the relationship between ABO blood groups and carcinoma of eso
phagus and cardia in Chaoshan inhabitants of China, which is a unique Litto
ral high-risk area of esophageal carcinoma in China. The poor communication
and transportation in the past has made Chaoshan a relatively closed area
and kept its culture and custure of old China thousand years ago.
METHODS Data on age, sex, ABO blood type and X-ray or pathological diagnose
of the patients with carcinoma of esophagus or cardia were collected from
the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital o
f Shantou University Medical College; and the Central Hospital of Shantou a
nd the Central Hospital of Jieyang. A total of 6 685 patients with esophage
al carcinoma (EC) and 2 955 patients with cardiac cancer (CC) in Chaoshan d
istrict were retrospectively assessed for their association with ABO blood
groups.
RESULTS The distribution of ABO blood groups in patients with EC or CC was
similar to the normal local population in Chaoshan. However, blood group B
in male patients with CC and in the patients with carcinoma in the upper th
ird esophagus was 2.3% and 4.7% higher than the corresponding controls. The
relative risk B: O was 1.1415 (P <0.05) and 1.2696 (P <0.05), respectively
. No relationship was found between ABO blood groups and tumor differentiat
ion.
CONCLUSION ABO blood group B is associated with the incidence of CC in male
individuals and carcinoma in the upper third esophagus. The distribution o
f ABO blood groups varies in the different geographical and ethnic groups.
As a result, proper controls are very important for such studies.