The relationship of histologic activity to serum ALT, HCV genotype and HCVRNA titers in chronic hepatitis C

Citation
Ys. Lee et al., The relationship of histologic activity to serum ALT, HCV genotype and HCVRNA titers in chronic hepatitis C, J KOR MED S, 16(5), 2001, pp. 585-591
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN journal
1011-8934 → ACNP
Volume
16
Issue
5
Year of publication
2001
Pages
585 - 591
Database
ISI
SICI code
1011-8934(200110)16:5<585:TROHAT>2.0.ZU;2-B
Abstract
It is unclear whether serum ALT levels or virological characteristics of he patitis C virus(HCV) including HCV genotypes and HCV RNA titers, can reflec t the degree of histological injury in chronic hepatitis C. The aim of this study was to investigate the relationships between the levels of histologi cal damage and serum ALT levels, HCV genotypes or circulating HCV RNA titer s in chronic hepatitis C. A total of 56 patients underwent liver biopsy and the histological activity index (HAI) was evaluated by Knodell's scoring s ystem. HCV genotype by RT-nested PCR and HCV RNA quantitation by competitiv e RT-PCR were performed. Thirty-four patients were infected with HCV genoty pe 1b, 20 patients with genotype 2a, and 2 patients with undetermined type. Serum ALT levels were not positively correlated with total HAI score or HC V RNA titers, but showed a linear correlation with scores of piecemeal necr osis (r=0.32, p <0.05) and portal inflammation (r=0.27, p <0.05). HCV genot ype had no significant correlation with RNA titers, HAI score or with serum ALT levels. Also, no statistical relationship was seen between HCV RNA tit er and HAI score. These results suggest that liver histology is essential t o evaluate the severity of chronic hepatitis C precisely.