Role of gancyclovir and HAART administration in the treatment of a rare complication of HIV disease: Cytomegalovirus-associated Guillain-Barre syndrome

Citation
L. Calza et al., Role of gancyclovir and HAART administration in the treatment of a rare complication of HIV disease: Cytomegalovirus-associated Guillain-Barre syndrome, J CHEMOTHER, 13(5), 2001, pp. 575-577
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology
Journal title
JOURNAL OF CHEMOTHERAPY
ISSN journal
1120-009X → ACNP
Volume
13
Issue
5
Year of publication
2001
Pages
575 - 577
Database
ISI
SICI code
1120-009X(200110)13:5<575:ROGAHA>2.0.ZU;2-I
Abstract
Peripheral nerve disorders are very common in patients with HIV infection, including inflammatory demyelinating polyneuropathies, such as Guillain-Bar re syndrome. Causes of these neuropathies are probably multiple, and often dictated by the stage of the underlying HIV disease. Acute demyelinating po lyneuropathy is usually preceded by infections, generally sustained by cyto megalovirus or Campylobacter jejuni, and a co-infection with HIV may repres ent the initial etiopathogenetic event leading to the neurological disorder . An extraordinary case report of a cytomegalovirus-associated Guillain-Bar re syndrome occurred in one of our patients with advanced HIV infection, wh o was cured by gancyclovir and HAART administration, and gives us the oppor tunity to briefly discuss the intriguing pathogenetic and clinical correlat ions among HIV disease, cytomegalovirus infection, this neurological syndro me, and its specific treatment.