Clinicopathological characteristics of estrogen receptor-beta-positive human breast cancers

Citation
Y. Miyoshi et al., Clinicopathological characteristics of estrogen receptor-beta-positive human breast cancers, JPN J CANC, 92(10), 2001, pp. 1057-1061
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
JAPANESE JOURNAL OF CANCER RESEARCH
ISSN journal
0910-5050 → ACNP
Volume
92
Issue
10
Year of publication
2001
Pages
1057 - 1061
Database
ISI
SICI code
0910-5050(200110)92:10<1057:CCOERH>2.0.ZU;2-B
Abstract
Recent studies have identified the presence of estrogen receptor (ER)-beta in addition to ER-alpha in human breast cancers, but the clinicopathologica l characteristics of ER-beta -positive tumors remain to be established. In this study, we have conducted an immunohistochemical analysis of ER-alpha a nd ER-beta expression in human breast cancers. In addition, we investigated the correlation of ER-alpha and ER-beta expression with progesterone recep tor (PR) status, determined by enzyme immunoassay, and with various clinico pathological factors. Of 79 tumors, 49 (62%) were positive for ER-alpha and 24 (30%) were positive for ER-beta, and there was no significant associati on between ER-alpha and ER-beta expression. ER-alpha -positive tumors were significantly more likely to be PR-positive than were ER-alpha -negative tu mors (P.<0.0001), but there was no significant association between ER-<beta > expression and PR status. However, the PR values of ER-alpha -positive an d ER-beta -positive tumors (65 +/- 17 fmol/mg protein, mean +/- SE) were ma rginally significantly lower than those of ER-alpha -positive and ER-beta - negative tumors (340 +/- 109) (P=0.08). ER-beta positivity was significantl y associated with small tumor size (less than or equal to2 cm) and high his tological grade (P<0.05), and this association was also observed when only ER-<alpha>-positive tumors were considered. These results suggest that dete rmination of ER-beta status might be clinically useful for further defining the characteristics of ER-alpha -positive tumors.