Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2 '-dimethyl-4-aminobiphenyl

Citation
T. Mori et al., Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2 '-dimethyl-4-aminobiphenyl, JPN J CANC, 92(10), 2001, pp. 1026-1033
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
JAPANESE JOURNAL OF CANCER RESEARCH
ISSN journal
0910-5050 → ACNP
Volume
92
Issue
10
Year of publication
2001
Pages
1026 - 1033
Database
ISI
SICI code
0910-5050(200110)92:10<1026:BTBNPO>2.0.ZU;2-C
Abstract
The modifying effects of three kinds of fat (corn oil, beef tallow or peril la oil, each at 20% in the diet) on F344 rat prostate carcinogenesis induce d by 3,2'-dimethyl-4-aminobiphenyl (DMAB) were investigated. Non-invasive c arcinomas of the ventral prostate were induced by DMAB alone and invasive c arcinomas of the other prostate lobes and seminal vesicles by DMAB and test osterone propionate (TP). Eight groups of F344 rats were initiated with 50 mg/kg body weight of DMAB at 2-week intervals for the first 20 weeks, four also receiving TP, extended until week 60. The animals received basal chow powder diet or one of three high fat diets throughout the experiment (60 we eks). One further group served as a non-carcinogen-treated control maintain ed on basal chow powder diet. Beef tallow significantly increased the devel opment of ventral prostate carcinomas with DMAB alone (from 15 to 45%, P<0. 05), while perilla oil reduced the incidence of prostatic intraepithelial n eoplasia (PIN) in the ventral lobe of rats given DMAB + TP (from 70 to 10%, P<0.01), but not in those given DMAB alone. No other effects of high fats were observed regarding PIN or invasive cancers of the dorsolateral and ant erior prostate or seminal vesicles. A satellite experiment demonstrated tha t all high fat diets for 4 weeks increased the 5-bromo-2-deoxyuridine (BrdU ) labeling index of prostate epithelial cells, suggesting that a high fat i ntake, irrespective of the fatty acid composition, may accelerate cell kine tics in the prostate. Of the three high fat diets, beef tallow was also fou nd to increase intestinal carcinogenesis. Thus, the present data revealed c arcinogenesis in the prostate and intestine to be promoted by beef tallow.