Alcohol, smoking, and dietary status and susceptibility to malignant lymphoma in Japan: Results of a hospital-based case-control study at Aichi Cancer Center

Citation
K. Matsuo et al., Alcohol, smoking, and dietary status and susceptibility to malignant lymphoma in Japan: Results of a hospital-based case-control study at Aichi Cancer Center, JPN J CANC, 92(10), 2001, pp. 1011-1017
Citations number
43
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
JAPANESE JOURNAL OF CANCER RESEARCH
ISSN journal
0910-5050 → ACNP
Volume
92
Issue
10
Year of publication
2001
Pages
1011 - 1017
Database
ISI
SICI code
0910-5050(200110)92:10<1011:ASADSA>2.0.ZU;2-K
Abstract
Recent increase in the incidence of malignant lymphoma (ML) suggests possib le involvement of lifestyle or environmental factors in its genesis. Howeve r, evidence for an effect of lifestyle factors, especially diet, on ML risk among Japanese is lacking. To explore the possibility that lifestyle facto rs exert an influence, we have conducted a hospital-based case-control stud y with 333 histologically confirmed ML cases and 55 904 non-cancer controls who first visited Aichi Cancer Center Hospital between 1988 and 1997. Mult iple logistic regression analysis showed regular alcohol consumption to be associated with reduced risk of ML, whereas no risk change was observed for smoking. Some other factors including intake of vegetables (carrots and pu mpkin), pork and fish showed partial associations, but their significance n eeds further clarification. From the previous study on genetic background f or ML [Matsuo et al., Blood, 97, 3205-3209 (2001)], genetic variation combi ned with limited environmental factors should be targeted in future studies .