Serous papillary adenocarcinomas of the ovary display heterogeneity in their response to chemotherapy

Citation
Sa. O'Toole et al., Serous papillary adenocarcinomas of the ovary display heterogeneity in their response to chemotherapy, INT J GYN C, 11(5), 2001, pp. 365-371
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine
Journal title
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
ISSN journal
1048-891X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
365 - 371
Database
ISI
SICI code
1048-891X(200109/10)11:5<365:SPAOTO>2.0.ZU;2-G
Abstract
The response of ovarian serous papillary adenocarcinomas to various cytotox ic drugs was examined using the (3-(4,5-dimethylthiazol-2-yl)-5(3-carboxyme thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) (MTS) cytotoxici ty assay. Thirty tumors were collected and organized into four groups accor ding to histologic grade and FIGO stage: stage III, grade 2; stage III, gra de 3; stage IV, grade 2; and stage IV, grade 3. The MTS chemosensitivity as say was performed on each tumor to examine the response to cisplatin, pacli taxel, hycamtin and the combination of cisplatin and paclitaxel. Ovarian ad enocarcinomas of similar stage and grade displayed varying responses to the same drug. A lower concentration of the drug was often as effective as the peak plasma concentration. For some specimens combination therapy was more effective for inhibiting tumor growth, and for others single-agent therapy gave a better response. A chemosensitivity/resistance profile is recommend ed before deciding on appropriate chemotherapy.