Placenta and myometrium - The two main sources of fibrinolytic components during pregnancy

Citation
M. Uszynski et al., Placenta and myometrium - The two main sources of fibrinolytic components during pregnancy, GYNECOL OBS, 52(3), 2001, pp. 189-193
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
52
Issue
3
Year of publication
2001
Pages
189 - 193
Database
ISI
SICI code
0378-7346(2001)52:3<189:PAM-TT>2.0.ZU;2-U
Abstract
Objectives: Placenta is a known source of some fibrinolytic components in p regnancy. The aim of the present study is to find out whether myometrium ca n be a parallel source. Study Design: The study group consisted of 34 women (16 primaparas and 18 multiparas, 39.0 +/- 0.2 years) in the 36-40th week of gestation with some obstetric complications: preeclampsia - 11, fetal di stress - 9, breech presentation - 3, placenta previa - 1, repeat caesarean birth - 10 cases (20 women were the control group). The strips of myometriu m as well as samples of venous blood and placenta were collected at the tim e of caesarean section. The tissue extracts were prepared. The components o f the plasminogen activator system were measured, i.e. tissue plasminogen a ctivator (tPA), urokinase plasminogen activator (uPA), plasminogen activato r inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2). An imm unoenzymatic method (ELISA) was used. Spearman and Pearson's correlation co efficients were the main tools of the statistical analysis. Results: The co ncentration of the fibrinolytic components in blood plasma, placenta and my ometrium were as follows (ng/mg of total protein): tPA: 0.15 +/- 0.07 blood plasma), 0.12 +/- 0.05 (placenta), and 1.42 +/- 1.02 (myometrium); uPA: 0. 01 +/- 0.005 (blood plasma), 1.09 +/- 0.25 (placenta), and 0.52 +/- 0.13 (m yometrium); PAI-1: 2.86 +/- 0.90 (blood plasma), 30.67 +/- 9.31 (placenta), and 22.29 +/- 11.29 (myometrium); PAI-2: 2.86 +/- 0.90 (blood plasma, 750. 89 +/- 170.29 (placenta), and 24.84 +/- 8.03 (myometrium). Conclusion: Besi des placenta, myometrium is another important source of fibrinolytic compon ents in pregnancy. Copyright (C) 2001 S. Karger AG, Basel.