Depot medroxy progesterone acetate: A poor preparatory agent for endometrial resection

Citation
A. Kriplani et al., Depot medroxy progesterone acetate: A poor preparatory agent for endometrial resection, GYNECOL OBS, 52(3), 2001, pp. 180-183
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
52
Issue
3
Year of publication
2001
Pages
180 - 183
Database
ISI
SICI code
0378-7346(2001)52:3<180:DMPAAP>2.0.ZU;2-A
Abstract
Objective: To evaluate the efficacy of depot medroxy progesterone acetate ( DMPA) as a preparatory agent for endometrial resection. Study Design:Endome trial resection was performed on 50 women for excessive uterine bleeding. T he patients were randomly divided into 2 equal groups, with the first group receiving DMPA and the second group not receiving any hormonal pre-medicat ion. The resected tissue was sent for histopathology and all the patients w ere followed up regularly for a maximum period of 4 years. Results: DMPA wa s found to increase the thickness of the endometrium, making it more fluffy and oedematous. The procedure in these patients was associated with a sign ificantly greater fluid consumption and deficit. A power analysis showed th e overall power of the study to be > 90%. Forty-four percent of group 1 and 64% of group 2 patients achieved amenorrhoea or spotting. Three patients i n all underwent a repeat procedure, and 1 a hysterectomy, following a dissa tisfactory result. However, no statistically significant difference was fou nd in the outcomes of the 2 groups. Conclusion: As a preparatory agent, DMP A, seems to have no added benefit. Larger studies are required to bring out differences in outcomes, if any. Copyright (C) 2001 S. Karger AG, Basel.