Risk factors for breast cancer among pre- or post-menopausal women in BeloHorizonte, Brazil

Citation
Alrr. Gomes et al., Risk factors for breast cancer among pre- or post-menopausal women in BeloHorizonte, Brazil, GYNECOL OBS, 52(3), 2001, pp. 173-179
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
52
Issue
3
Year of publication
2001
Pages
173 - 179
Database
ISI
SICI code
0378-7346(2001)52:3<173:RFFBCA>2.0.ZU;2-U
Abstract
Background: Much controversy has been generated about pre- and post-menopau sal breast cancer patients and investigators have sought to identify whethe r risk factors differ between these two groups. In Brazil, breast cancer is an important cause of death among women and there are few analytical studi es concerning pre- or post-menopausal comparisons. Methods: A case-control study was carried out at the Federal University Hospital, Belo Horizonte, B razil, to determine if selected socio-economic and reproductive risk factor s for breast cancer differed between pre-menopausal and post-menopausal wom en. Cases were 300 women with breast carcinoma and controls were 600 women with other benign diseases matched for age and date of diagnosis, admitted to the same hospital during the same period (1978-1987). Univariate and mul tivariate conditional logistic regression analyses were performed. Results: Multivariate analysis showed no differences in breast cancer risk in pre- and post-menopausal women (risk factors were similar in direction and magni tude). Occupation, irregular menstrual cycles, parity, history of breast ca ncer in at least one first-degree female relative, and oral contraceptive u se had similar associations in both groups. Conclusions: The present study indicates that breast cancer diagnosed before and after menopause has a sim ilar risk profile. Copyright (C) 2001 S. Karger AG, Basel.