Sh. Shim et al., Immunohistochemical detection of tyrosine hydroxylase and concentrations of monoamines in the substantia nigra and hypothalamus of hereditary microphthalmic rats, EXP ANIM, 50(5), 2001, pp. 445-449
We compared tyrosine hydroxylase immunoreactivity in the substantia nigra a
nd hypothalamus of hereditary microphthalmic rats with that of normal rats.
A considerable number of neuronal cell bodies expressing tyrosine hydroxyl
ase were present in the substantia nigra of the microphthalmic mutant as we
ll as normal rats. Neuronal cells positive for tyrosine hydroxylase in the
hypothalamus were fewer than in the substantia nigra in both rats. The conc
entrations of monoamines (dopamine, noradrenaline, adrenaline, and serotoni
n) in the substantia nigra and hypothalamus in the microphthalmic mutant we
re approximately the same as those of normal rats, although the diurnal flu
ctuation of a few monoamines was observed in normal rats. These results sug
gest that the metabolic aspects of catecholamine in the substantia nigra an
d hypothalamus of the microphthalmic mutant rat do not markedly differ from
those of normal rats.