Immunohistochemical detection of tyrosine hydroxylase and concentrations of monoamines in the substantia nigra and hypothalamus of hereditary microphthalmic rats

Citation
Sh. Shim et al., Immunohistochemical detection of tyrosine hydroxylase and concentrations of monoamines in the substantia nigra and hypothalamus of hereditary microphthalmic rats, EXP ANIM, 50(5), 2001, pp. 445-449
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Animal Sciences
Journal title
EXPERIMENTAL ANIMALS
ISSN journal
1341-1357 → ACNP
Volume
50
Issue
5
Year of publication
2001
Pages
445 - 449
Database
ISI
SICI code
1341-1357(200110)50:5<445:IDOTHA>2.0.ZU;2-H
Abstract
We compared tyrosine hydroxylase immunoreactivity in the substantia nigra a nd hypothalamus of hereditary microphthalmic rats with that of normal rats. A considerable number of neuronal cell bodies expressing tyrosine hydroxyl ase were present in the substantia nigra of the microphthalmic mutant as we ll as normal rats. Neuronal cells positive for tyrosine hydroxylase in the hypothalamus were fewer than in the substantia nigra in both rats. The conc entrations of monoamines (dopamine, noradrenaline, adrenaline, and serotoni n) in the substantia nigra and hypothalamus in the microphthalmic mutant we re approximately the same as those of normal rats, although the diurnal flu ctuation of a few monoamines was observed in normal rats. These results sug gest that the metabolic aspects of catecholamine in the substantia nigra an d hypothalamus of the microphthalmic mutant rat do not markedly differ from those of normal rats.