Lack of evidence for an association between two genetic polymorphisms in the tumor necrosis factor receptor 1 gene and multiple sclerosis in Ashkenazi Jews

Citation
E. Pras et al., Lack of evidence for an association between two genetic polymorphisms in the tumor necrosis factor receptor 1 gene and multiple sclerosis in Ashkenazi Jews, EUR NEUROL, 46(3), 2001, pp. 153-155
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
EUROPEAN NEUROLOGY
ISSN journal
0014-3022 → ACNP
Volume
46
Issue
3
Year of publication
2001
Pages
153 - 155
Database
ISI
SICI code
0014-3022(2001)46:3<153:LOEFAA>2.0.ZU;2-K
Abstract
Multiple sclerosis (MS) is a multifactorial disease with a documented genet ic component. Recent experimental models suggested a role for the tumor nec rosis factor receptor 1 (TNFR1) in the pathogenesis of the disease. We comp ared the frequency of two polymorphisms from TNFR1, located in exon 1 and i ntron 6, in 94 Jewish Ashkenazi MS patients and 83 healthy Ashkenazi contro ls. No significant differences were observed for both polymorphisms between the patients and the controls. These findings suggest that genetic variant s in TNFR1 do not play a significant role in Ashkenazi Jews. Copyright (C) 2001 S. Karger AG, Basel.