Frequency of isolation and antimicrobial resistance of gram-negative and gram-positive bacteria from patients in intensive care units of 25 European university hospitals participating in the European arm of the SENTRY Antimicrobial Surveillance Program 1997-1998

Citation
Ac. Fluit et al., Frequency of isolation and antimicrobial resistance of gram-negative and gram-positive bacteria from patients in intensive care units of 25 European university hospitals participating in the European arm of the SENTRY Antimicrobial Surveillance Program 1997-1998, EUR J CL M, 20(9), 2001, pp. 617-625
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
ISSN journal
0934-9723 → ACNP
Volume
20
Issue
9
Year of publication
2001
Pages
617 - 625
Database
ISI
SICI code
0934-9723(200109)20:9<617:FOIAAR>2.0.ZU;2-O
Abstract
A total of 3,981 isolates from patients treated at intensive care units wer e collected in 25 European university hospitals during 1997 and 1998 as par t of the SENTRY Antimicrobial Surveillance Program. Overall, the most impor tant species isolated were Staphylococcus aureus. Pseudomonas aeruginosa, E scherichia coli, coagulase-negative staphylococci (CNS), Enterobacter spp., Haemophilus influenzae, Streptococcus pneumoniae, and Enterococcus faecali s. Thirty-nine percent of all Staphylococcus aureus isolates were resistant to oxacillin. All Staphylococcus aureus isolates were fully susceptible to linezolid and vancomycin. Moreover. all CNS isolates were susceptible to v ancomycin and minocycline. All Enterococcus faecalis isolates were suscepti ble to vancomycin, and 99% of these isolates were also susceptible to ampic illin. The antimicrobial agents most effective against Pseudomonas aerugino sa isolates were amikacin. piperacillin/tazobactam, meropenem, and cefepime , with 87, 85, 84, and 83% of isolates being susceptible. respectively. Esc herichia coli isolates were fully susceptible to carbapenems, and at least 99% of these isolates were susceptible to ceftriaxone, cefepime, and amikac in. The Enterobacter spp. were also highly susceptible to carbapenems, amik acin, and cefepime, with 99, 97, and 96% of isolates being susceptible, res pectively. Haemophilus influenzae was susceptible to most of the antibiotic s tested. Only 68% of the pneumococcal isolates were fully susceptible to p enicillin, yet 100% were susceptible to a number of fluoroquinolones and va ncomycin. There are still sufficient treatment options for patients infecte d with the most important bacterial species involved in infections in inten sive care units. However, the situation for patients with Pseudomonas aerug inosa infections is critical.