Hypoxic brain damage after intramuscular self-injection of diclofenac for acute back pain

Citation
Wr. Schabitz et al., Hypoxic brain damage after intramuscular self-injection of diclofenac for acute back pain, EUR J ANAES, 18(11), 2001, pp. 763-765
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care
Journal title
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
ISSN journal
0265-0215 → ACNP
Volume
18
Issue
11
Year of publication
2001
Pages
763 - 765
Database
ISI
SICI code
0265-0215(200111)18:11<763:HBDAIS>2.0.ZU;2-E
Abstract
We present a case of hypoxic brain damage that occurred after intramuscular injection of diclofenac due to a severe anaphylactic reaction. A 38-year-o ld nurse treated herself for acute lower back pain with 100 mg diclofenac i ntramuscularly. Five minutes later, she collapsed and developed coma and re spiratory arrest. After cardiopulmonary resuscitation she was transferred t o hospital. On admission she was comatose and received controlled ventilati on of the lungs. Magnetic resonance imaging and computerized tomography sho wed signs of hypoxic brain injury and the patient died from central cardiop ulmonary failure 7 days later. Intramuscular treatment with non-steroidal a nti-inflammatory drugs such as diclofenac has rare but potentially severe s ide-effects. Therefore, intramuscular injections are inappropriate and shou ld tie replaced with oral or rectal treatment, which has similar absorption profiles.