Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents

Citation
K. Iwasa et al., Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents, BIO MED CH, 9(11), 2001, pp. 2871-2884
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
0968-0896 → ACNP
Volume
9
Issue
11
Year of publication
2001
Pages
2871 - 2884
Database
ISI
SICI code
0968-0896(200111)9:11<2871:SIABAA>2.0.ZU;2-D
Abstract
Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simpl e isoquinoline alkaloids were significantly active in each assay, and may b e useful as lead compounds for developing potential chemotherapeutic agents . These compounds include 13 (antimicrobial), 25, 26, and 42 (antimalarial) , 13 and 25 (cytotoxic), and 28 and 29 (anti-HIV). A quaternary nitrogen at om of isoquinolium or dihydroisoquinolinium type may contribute to enhanced potency in the first three types of activities. In contrast, anti-HIV acti vity was found with tetrahydroisoquinoline and 6,7-dihydroxyisoquinolium sa lts. (C) 2001 Elsevier Science Ltd. All rights reserved.