Stimulation of ERK2 by taurine with enhanced alkaline phosphatase activityand collagen synthesis in osteoblast-like UMR-106 cells

Citation
S. Park et al., Stimulation of ERK2 by taurine with enhanced alkaline phosphatase activityand collagen synthesis in osteoblast-like UMR-106 cells, BIOCH PHARM, 62(8), 2001, pp. 1107-1111
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOCHEMICAL PHARMACOLOGY
ISSN journal
0006-2952 → ACNP
Volume
62
Issue
8
Year of publication
2001
Pages
1107 - 1111
Database
ISI
SICI code
0006-2952(20011015)62:8<1107:SOEBTW>2.0.ZU;2-D
Abstract
Taurine is present in a variety of tissues and exhibits many important phys iological functions in the cell. Even though its functions are well documen ted in many tissues, its actions on bone cells are largely unknown. Conside ring a recent finding that taurine is present in the bone, we wished to det ermine if taurine could have any effects on osteoblast cells. Taurine (10 m M) stimulated alkaline phosphatase activity as well as collagen synthesis. Taurine also stimulated tyrosine phosphorylation of a number of cellular pr oteins including a 42-kDa protein. The 42-kDa protein was identified as ext racellular signal regulated protein kinase 2 (ERK22). A mitogen-activated p rotein kinase kinase (MEK) inhibitor blocked the taurine-stimulated alkalin e phosphatase activity and colla gen synthesis. These results suggest that taurine could regulate osteoblast metabolism via ERK2 activation. (C) 2001 Elsevier Science Inc. All rights reserved.