Bacteriophage therapy

Authors
Citation
Wc. Summers, Bacteriophage therapy, ANN R MICRO, 55, 2001, pp. 437-451
Citations number
65
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
55
Year of publication
2001
Pages
437 - 451
Database
ISI
SICI code
0066-4227(2001)55:<437:BT>2.0.ZU;2-B
Abstract
In 1917, bacteriophages were recognized as epizootic infections of bacteria and were almost immediately deployed for antibacterial therapy and prophyl axis. The early trials of bacteriophage therapy for infectious diseases wer e confounded, however, because the biological nature of bacteriophage was p oorly understood. The early literature reviewed here indicates that there a re good reasons to believe that phage therapy can be effective in some circ umstances. The advent of antibiotics, together with the "Soviet taint" acqu ired by phage therapy in the postwar period, resulted in the absence of rig orous evaluations of phage therapy until very recently. Recent laboratory a nd animal studies, exploiting current understandings of phage biology, sugg est that phages may be useful as antibacterial agents in certain conditions .