Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery

Citation
Jw. Campbell et Je. Cronan, Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery, ANN R MICRO, 55, 2001, pp. 305-332
Citations number
127
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
55
Year of publication
2001
Pages
305 - 332
Database
ISI
SICI code
0066-4227(2001)55:<305:BFABTF>2.0.ZU;2-M
Abstract
The increase in drug-resistant pathogenic bacteria has created an urgent de mand for new antibiotics. Among the more attractive targets for the develop ment of new antibacterial compounds are the enzymes of fatty acid biosynthe sis. Although a number of potent inhibitors of microbial fatty acid biosynt hesis have been discovered, few of these are clinically useful drugs. Sever al of these fatty acid biosynthesis inhibitors have potential as lead compo unds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.