Phages of dairy bacteria

Authors
Citation
H. Brussow, Phages of dairy bacteria, ANN R MICRO, 55, 2001, pp. 283-303
Citations number
98
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
55
Year of publication
2001
Pages
283 - 303
Database
ISI
SICI code
0066-4227(2001)55:<283:PODB>2.0.ZU;2-V
Abstract
Bacteriophages of lactic acid bacteria are a threat to industrial milk ferm entation. Owing to their economical importance, dairy phages became the mos t thoroughly sequenced phage group in the database. Comparative genomics id entified related cos-site and pac-site phages, respectively, in lactococci, lactic streptococci and lactobacilli. Each group was represented with clos ely related temperate and virulent phages. Over the structural genes their gene maps resembled that of lambdoid coliphages, suggesting distant evoluti onary relationships. Despite a lack of sequence similarity, a number of bio chemical characteristics of these dairy phages are lambda-like (genetic swi tch, DNA packaging, head and tail morphogenesis, and integration, but not e xcision). These dairy phages thus provide interesting variations to the pha ge lambda paradigm. The structural gene cluster of Lactococcus phage r1t re sembled that of phages from mycobacteria. Virulent lactococcal phages with prolate heads (c2-like genus of Siphoviridae), in contrast, have no known c ounterparts in other bacterial genera.