Nonreplicating persistence of Mycobacterium tuberculosis

Citation
Lg. Wayne et Cd. Sohaskey, Nonreplicating persistence of Mycobacterium tuberculosis, ANN R MICRO, 55, 2001, pp. 139-163
Citations number
139
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
55
Year of publication
2001
Pages
139 - 163
Database
ISI
SICI code
0066-4227(2001)55:<139:NPOMT>2.0.ZU;2-A
Abstract
There is ample clinical evidence, as well as evidence from animal experimen ts, that Mycobacterium tuberculosis can persist in tissues for months to de cades without replicating, yet with the ability to resume growth and activa te disease. Our knowledge of both macrophage physiology and the nature of t uberculous lesions in man and animals suggests that hypoxia is a major fact or in inducing nonreplicating persistence (NRP) of tubercle bacilli. In vit ro models reinforce this conclusion and provide insights into mechanisms th at make NRP possible. There is evidence from in vitro models that the strat egies employed by the bacilli to permit hypoxic NRP include restriction of biosynthetic activity to conserve energy, induction of alternative energy p athways, and stabilization of essential cell components to lessen the need for repair or replacement.