Topical tretinoin 0.1% for pregnancy-related abdominal striae: An open-label, multicenter, prospective study

Citation
O. Rangel et al., Topical tretinoin 0.1% for pregnancy-related abdominal striae: An open-label, multicenter, prospective study, ADV THER, 18(4), 2001, pp. 181-186
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology
Journal title
ADVANCES IN THERAPY
ISSN journal
0741-238X → ACNP
Volume
18
Issue
4
Year of publication
2001
Pages
181 - 186
Database
ISI
SICI code
0741-238X(200107/08)18:4<181:TT0FPA>2.0.ZU;2-5
Abstract
In an open-label, multicenter, prospective study, 20 women applied tretinoi n (retinoic acid) cream 0.1 % daily for 3 months to pregnancy-related stret ch marks in the abdominal area. Efficacy was evaluated by analysis of one p reselected target lesion, which was rated on a six-point scale (-1 = worse to 4 = cleared). At week 12, significant global improvement was noted from baseline in all stretch marks, and the target lesion decreased in length by 20% (P = .01). Erythema and scaling, the most common adverse events, occur red in I I patients, decreased in severity after the first month of treatme nt, and were controlled with continued application of tretinoin and petrole um jelly ointment. In this small study, topical application of tretinoin si gnificantly improved the-clinical appearance of pregnancy-related stretch m arks.