Pharmacological control of platelet function

Citation
P. Clutton et al., Pharmacological control of platelet function, PHARMAC RES, 44(4), 2001, pp. 255-264
Citations number
136
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACOLOGICAL RESEARCH
ISSN journal
1043-6618 → ACNP
Volume
44
Issue
4
Year of publication
2001
Pages
255 - 264
Database
ISI
SICI code
1043-6618(200110)44:4<255:PCOPF>2.0.ZU;2-Y
Abstract
Advancement in the understanding of the mechanisms of platelet activation, as well as the development of new techniques for studying platelet function , have led to the availability of new classes of platelet inhibiting drugs. Initially, characterization of arachidonic acid metabolism in platelets fu rthered an understanding of the utility of cyclooxygenase inhibitors, most notably aspirin. The discovery and characterization of platelet receptors s uch as the adenosine diphosphate (ADP) receptor and glycoprotein IIb/IIIa h as been associated with the development of novel classes of anti-platelet d rug, such as thienopyridine derivatives and glycoprotein IIb/IIIa receptor antagonists, respectively. Future development in receptor pathway inhibitor s also includes glycoprotein Ib/IX as well as the potential use of platelet signaling pathway inhibitors. (C) 2001 Academic Press.