Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray

Citation
R. Yanagawa et al., Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray, NEOPLASIA, 3(5), 2001, pp. 395-401
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
NEOPLASIA
ISSN journal
1522-8002 → ACNP
Volume
3
Issue
5
Year of publication
2001
Pages
395 - 401
Database
ISI
SICI code
1522-8002(200109/10)3:5<395:GSOGSA>2.0.ZU;2-6
Abstract
In spite of intensive and increasingly successful attempts to determine the multiple steps involved in colorectal carcinogenesis, the mechanisms respo nsible for metastasis of colorectal tumors to the liver remain to be clarif ied. To identify genes that are candidates for involvement in the metastati c process, we analyzed genome-wide expression profiles of 10 primary colore ctal cancers and their corresponding metastatic lesions by means of a cDNA microarray consisting of 9121 human genes. This analysis identified 40 gene s whose expression was commonly upregulated in metastatic lesions, and 7 th at were commonly downregulated. The upregulated genes encoded proteins invo lved in cell adhesion, or remodeling of the actin cytoskeleton. Investigati on of the functions of more of the altered genes should improve our underst anding of metastasis and may identify diagnostic markers and/or novel molec ular targets for prevention or therapy of metastatic lesions.