The fat-derived hormone adiponectin reverses insulin resistance associatedwith both lipoatrophy and obesity

Citation
T. Yamauchi et al., The fat-derived hormone adiponectin reverses insulin resistance associatedwith both lipoatrophy and obesity, NAT MED, 7(8), 2001, pp. 941-946
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
1078-8956 → ACNP
Volume
7
Issue
8
Year of publication
2001
Pages
941 - 946
Database
ISI
SICI code
1078-8956(200108)7:8<941:TFHARI>2.0.ZU;2-J
Abstract
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where the gene encoding adiponectin is located. Here we s how that decreased expression of adiponectin correlates with insulin resist ance in mouse models of altered insulin sensitivity. Adiponectin decreases insulin resistance by decreasing triglyceride content in muscle and liver i n obese mice. This effect results from increased expression of molecules in volved in both fatty-acid combustion and energy dissipation in muscle. More over, insulin resistance in lipoatrophic mice was completely reversed by th e combination of physiological doses of adiponectin and leptin, but only pa rtially by either adiponectin or leptin alone. We conclude that decreased a diponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy. These data also indicate that the r eplenishment of adiponectin might provide a novel treatment modality for in sulin resistance and type 2 diabetes.