Reaction of 2-aminopyrazine 1 with isothiocyanate. isocyanate or dithioketa
l reagent furnished pteridines 3,4 in good yield. Thioxo compound 3a was ch
lorinated, methylated and subsequently displaced by amines. A simple one-st
ep synthesis of heterocondensed pteridines 8-13 by reaction of 2-aminopyraz
ine with various imino thioacetals was described 8-13.