Studies on the chemical transformations of rotenoids. 6 Synthesis and antitumor-promoting activity of [1]benzofuro[2,3-d]pyridazines fused with 1,2,4-triazole, 1,2,4-triazine and 1,2,4-triazepine

Citation
S. Nagai et al., Studies on the chemical transformations of rotenoids. 6 Synthesis and antitumor-promoting activity of [1]benzofuro[2,3-d]pyridazines fused with 1,2,4-triazole, 1,2,4-triazine and 1,2,4-triazepine, J HETERO CH, 38(5), 2001, pp. 1097-1101
Citations number
3
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022-152X → ACNP
Volume
38
Issue
5
Year of publication
2001
Pages
1097 - 1101
Database
ISI
SICI code
0022-152X(200109/10)38:5<1097:SOTCTO>2.0.ZU;2-#
Abstract
[1]Benzofuro[2,3-d]pyridazines fused with 1,2,4-triazole (6 and 7), 1,2,4-t riazine (8-10) and 1,2,4-triazepine (12) were prepared by the ring closure of 4-hydrazino-[1]benzofuro[2,3-d]pyridazine (5), derived from naturally oc curring rotenone. Compounds (1a and 1b) exhibited significant inhibitory ac tivity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-B arr virus early antigen (EBA-EA) activation in Raji cells. In contrast, the fused [I]benzofuro[2,3-d]pyridazines except 6c and 8 were quite inactive.