It has become widely accepted that adhesion receptors can either directly a
ctivate, or significantly modulate, many of the signaling cascades initiate
d by circulating growth factors. An interesting recent development is the r
ealization that adhesion receptors and their cytoskeletal partners can regu
late the trafficking of signaling proteins between the cytoplasm and nucleu
s. Cell adhesion molecule control of nucleocytoplasmic trafficking allows a
dhesion to influence many cell decisions, and highlights the diversity of n
uclear import and export mechanisms.