Postural tachycardia syndrome is defined as the development of orthostatic
symptoms without orthostatic hypotension. We report a 28-year-old female pa
tient with postural tachycardia syndrome who exhibited palpitation, low-gra
de fever and weight loss. Evaluation of autonomic nervous system functions
showed that cardiovagal function was normal. Sweat response to acetylcholin
e was decreased. Excessive blood pressure elevation was seen in phase IV of
the Valsalva maneuver. Pathophysiologic factors in this case were consider
ed to be alpha adrenergic denervation and beta adrenergic hyperresponsivene
ss. It is important that this syndrome be widely recognized and properly di
agnosed.