Genomic structures and population histories of linguistically distinct tribal groups of India

Citation
S. Roychoudhury et al., Genomic structures and population histories of linguistically distinct tribal groups of India, HUM GENET, 109(3), 2001, pp. 339-350
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN GENETICS
ISSN journal
0340-6717 → ACNP
Volume
109
Issue
3
Year of publication
2001
Pages
339 - 350
Database
ISI
SICI code
0340-6717(200109)109:3<339:GSAPHO>2.0.ZU;2-C
Abstract
There are various conflicting hypotheses regarding the origins of the triba l groups of India, who belong to three major language groups - Austro-Asiat ic, Dravidian and Tibeto-Burman. To test some of the major hypotheses we de signed a genetic study in which we sampled tribal populations belonging to all the three language groups. We used a set of autosomal DNA markers, mtDN A restriction-site polymorphisms (RSPs) and mtDNA hypervariable segment-1 ( HVS-1) sequence polymorphisms in this study. Using the unlinked autosomal m arkers we found that there is a fair correspondence between linguistic and genomic affinities among the Indian tribal groups. We reconstructed mtDNA R SP haplotypes and found that there is extensive haplotype sharing among all tribal populations. However, there is very little sharing of mtDNA HVS-1 s equences across populations, and none across language groups. Haplogroup M is ubiquitous, and the subcluster U2i of haplogroup U occurs in a high freq uency. Our analyses of haplogroup and HVS-1 sequence data provides evidence in support of the hypothesis that the Austro-Asiatic speakers are the most ancient inhabitants of India. Our data also support the earlier finding th at some of the western Eurasian haplogroups found in India may have been pr esent in India prior to the entry of Aryan speakers. However, we do not fin d compelling evidence to support the theory that haplogroup M was brought i nto India on an "out of Africa" wave of migration through a southern exit r oute from Ethiopia. On the contrary, our data raise the possibility that th is haplogroup arose in India and was later carried to East Africa from Indi a.