Lack of an association of a single nucleotide polymorphism in the promoterof the matrix metalloproteinase-1 gene in Czech women with pregnancy-induced hypertension

Citation
M. Jurajda et al., Lack of an association of a single nucleotide polymorphism in the promoterof the matrix metalloproteinase-1 gene in Czech women with pregnancy-induced hypertension, GYNECOL OBS, 52(2), 2001, pp. 124-127
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
52
Issue
2
Year of publication
2001
Pages
124 - 127
Database
ISI
SICI code
0378-7346(2001)52:2<124:LOAAOA>2.0.ZU;2-K
Abstract
In preeclampsia the cytotrophoblast invasion of the deck dual vessels is re duced. The endothelia in the decidual vessels may influence cytotrophoblast invasion and remodeling of decidual spiral arteries. The decidual endothel ial cells from preeclamptic placentas produce less matrix metalloproteinase -1 (MMP1) than those from normal placentas. MMPs form a group of enzymes th at are capable of degrading components of extracellular matrix. The present study investigated the prevalence and possible association of an insertion of guanine in the promoter of the MMPI gene in pregnancy-induced hypertens ion, preeclampsia and eclampsia in the Czech population. This was a case-co ntrol study. No differences were observed in genotype frequencies between c ases and controls. The insertion of the guanine in the promoter of the MMP1 gene does not appear to increase the risk of development of pregnancy-indu ced hypertension, preeclampsia and eclampsia. Copyright (C) 2001 S. Karger AG.