Influence of preeclampsia or maternal intake of omega-3 fatty acids on thevasoactive effect of prostaglandin F-two-alpha in human umbilical arteries

Citation
G. Haugen et I. Helland, Influence of preeclampsia or maternal intake of omega-3 fatty acids on thevasoactive effect of prostaglandin F-two-alpha in human umbilical arteries, GYNECOL OBS, 52(2), 2001, pp. 75-81
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
52
Issue
2
Year of publication
2001
Pages
75 - 81
Database
ISI
SICI code
0378-7346(2001)52:2<75:IOPOMI>2.0.ZU;2-D
Abstract
The vasoactive effect of prostaglandin F-2 alpha (PGF(2 alpha)) was studied in in vitro perfused human umbilical arteries following maternal dietary s upplementation with omega -3 fatty acids or in pregnancies complicated by a moderate degree of preeclampsia. In most preparations PGF(2 alpha) induced a biphasic pressure response with a transient dilatation followed by a con strictory response. The pressure increase was significant in both groups, b ut no significant differences in the constrictory response or in the propor tions of preparations displaying dilatatory responses were observed when co mpared to appropriate control groups. In conclusion, neither preeclampsia n or dietary supplementation with cod-liver oil had any significant effect on the vasoactive response to PGF(2 alpha) in umbilical cord arteries. Copyri ght (C) 2001 S. Karger AG, Basel.