Imaging of the endothelial dysfunction in coronary atherosclerosis

Citation
Jt. Kuikka et al., Imaging of the endothelial dysfunction in coronary atherosclerosis, EUR J NUCL, 28(10), 2001, pp. 1567-1578
Citations number
100
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
ISSN journal
0340-6997 → ACNP
Volume
28
Issue
10
Year of publication
2001
Pages
1567 - 1578
Database
ISI
SICI code
0340-6997(200110)28:10<1567:IOTEDI>2.0.ZU;2-3
Abstract
Coronary endothelial dysfunction is characterised by coronary vasoconstrict ive responses to endothelium-dependent vasodilators. It is associated with coronary artery disease (CAD) and is considered an early phase of coronary atherosclerosis. Patients with CAD benefit from vigorous risk factor interv entions and medical treatment, with a marked decrease in coronary events an d an improvement in survival that are not reported following revascularisat ion procedures. Therefore, early detection of anatomical and functional cha nges in the coronary vasculature due to atherosclerosis provides the basis for integrated pharmacological, dietary and lifestyle modifications to prev ent cardiovascular events and revascularisation procedures. The question ar ises as to whether these alterations in regional myocardial tone can be det ected by any of the current non-invasive methods. Several methods are revie wed. We consider that intracoronary ultrasonography is the most accurate me thod, but non-invasive positron emission tomography and magnetic resonance imaging technology is of growing importance for identifying endothelial dys function of early coronary atherosclerosis.