Relationship between thallium-201 kinetics and proliferative activity assessed by monoclonal antibody MIB-1 in brain tumours

Citation
K. Motoyama et al., Relationship between thallium-201 kinetics and proliferative activity assessed by monoclonal antibody MIB-1 in brain tumours, EUR J NUCL, 28(10), 2001, pp. 1471-1481
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
ISSN journal
0340-6997 → ACNP
Volume
28
Issue
10
Year of publication
2001
Pages
1471 - 1481
Database
ISI
SICI code
0340-6997(200110)28:10<1471:RBTKAP>2.0.ZU;2-1
Abstract
To clarify the relationship between thallium-201 chloride kinetics and prol iferative activity in brain tumours, a single-photon emission tomographic ( SPET) study was performed and the results correlated with monoclonal antibo dy MIB-1 staining of the tumour tissue. (TI)-T-201 SPET was performed 10 mi n (early scan) and 2 h (delayed scan) after intravenous administration of ( TI)-T-201 (111 MBq) in 34 intra-axial tumours including 24 malignant tumour s. and in 27 extra-axial tumours including one malignant tumour. Tumour (TI )-T-201 kinetic parameters [early and delayed uptake ratios (ER and DR, res pectively), retention index (RI), and the ratio of tumour delayed activity to early activity (Td/Te)] were compared with tumour tissue MIB-1 labelling indices (MIB-1 Lt) representative of tumour cell proliferative activity. I n the intra-axial tumours, ER and DR and MIB-1 LI were significantly higher in the malignant tumours. than in the benign tumours. ER and DR were signi ficantly correlated with MIB-1 LI (P <0.01 and P <0.05, respectively), but RI and Td/Te were not. In the extra-axial benign tumours, ER was as high as that in the intra-axial malignant tumours, while MIB-1 Lt was equal to tha t in the intra-axial benign tumours. There were no significant correlations between any (TI)-T-201 kinetic parameters and MIB-1 Lt. This study indicat es that (TI)-T-201 ER may be the most reliable parameter for predicting the proliferative activity of intra-axial tumours.