Translocation (14;19)(q32;q13) detected by spectral karyotyping and lack of BCL3 rearrangement in CD5-positive B-cell lymphoma associated with hemophagocytic syndrome

Citation
K. Yamamoto et al., Translocation (14;19)(q32;q13) detected by spectral karyotyping and lack of BCL3 rearrangement in CD5-positive B-cell lymphoma associated with hemophagocytic syndrome, CANC GENET, 130(1), 2001, pp. 38-41
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
0165-4608 → ACNP
Volume
130
Issue
1
Year of publication
2001
Pages
38 - 41
Database
ISI
SICI code
0165-4608(20011001)130:1<38:T(DBSK>2.0.ZU;2-1
Abstract
It has been shown that some cases of B-cell non-Hodgkin lymphoma associated with a hemophagocytic syndrome (B-LAHS) have chromosomal abnormalities at 14q32 or 19q13. We report here a 64-year-old woman with B-LAHS and a comple x karyotype including add(14)(q32). We applied spectral karyotyping and rev ealed that the add(14)(q32) was derived from a der(14)t(14;19)(q32;q13). Ho wever, rearrangement of the BCL3 gene at 19q13 could not be detected by Sou thern blot analysis. Our results indicate that the translocation involving, , 19q13 may be one of the recurrent aberrations in B-LAHS and that the mole cular mechanism of t(14;19)(q32;q13) in B-LAHS appear to be different from that observed in chronic lymphocytic leukemia. (C) 2001 Elsevier Science In c. All rights reserved.