Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria

Citation
Sh. Kim et al., Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria, AM J P-REG, 281(5), 2001, pp. R1456-R1463
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physiology
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
ISSN journal
0363-6119 → ACNP
Volume
281
Issue
5
Year of publication
2001
Pages
R1456 - R1463
Database
ISI
SICI code
0363-6119(200111)281:5<R1456:AOIEOC>2.0.ZU;2-2
Abstract
It has been shown that atrial natriuretic peptide (ANP) influences prolifer ation of cardiac cells. To define the possible role of C-type natriuretic p eptide (CNP) in cardiac hypertrophy, the influence of CNP on the secretion of ANP was studied with the use of perfused nonbeating atria from monocrota line-treated rats. Increases in atrial volume caused proportional increases in ANP secretion that were markedly suppressed by CNP (10(-6) M) in nonhyp ertrophied left atria and control right atria but not in hypertrophied righ t atria. However, increases in atrial volume and mechanically stimulated ex tracellular fluid (ECF) translocation by CNP were similar to those in the c ontrol group. Therefore, the secretion of ANP in terms of ECF translocation was decreased by CNP in nonhypertrophied left and control right atria but not in hypertrophied atria. However, the inhibitory effect of 8-bromo-cGMP on the secretion of ANP was observed in both atria. The cGMP productions fr om perfused hypertrophied atria and their membranes exposed to CNP were sig nificantly lower than those from nonhypertrophied atria. No significant dif ference in natriuretic peptide receptor-B transcript was found. Therefore, attenuation of the inhibitory effect of CNP on the ANP secretion in hypertr ophied atria may be due to lack of cGMP production. The results showing the relief of CNP-induced negative inhibition of ANP secretion by atrial hyper trophy suggest that CNP may be a contributing factor to delay the developme nt of cardiac hypertrophy.