Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervation

Authors
Citation
Y. Huang et Dh. Wang, Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervation, AM J P-HEAR, 281(5), 2001, pp. H2143-H2149
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
ISSN journal
0363-6135 → ACNP
Volume
281
Issue
5
Year of publication
2001
Pages
H2143 - H2149
Database
ISI
SICI code
0363-6135(200111)281:5<H2143:RORSIS>2.0.ZU;2-T
Abstract
To define the role of the renin-angiotensin-aldosterone system in a novel s alt-sensitive model, neonatal Wistar rats were given capsaicin (50 mg/kg sc ) on the first and second days of life. After weaning, male rats were divid ed into the following six groups and treated for 3 wk with: control + norma l sodium diet (CONNS), CON + high- sodium diet (CON-HS), CON + HS + spirono lactone (50 mg.kg(-1).day(-1), CON-HS-SP), capsaicin pretreatment + NS (CAP -NS), CAP-HS, and CAP-HS-SP. Radioimmunoassay shows that plasma renin activ ity (PRA) and plasma aldosterone level (PAL) were suppressed by HS, but the y were higher in CAP-HS than in CON-HS and CON-HS-SP (P<0.05). Both tail-cu ff systolic blood pressure and mean arterial pressure were higher in CAP-HS than in all other groups (P<0.05). Urine water and sodium excretion were i ncreased with HS intake, but they were lower in CAP-HS than in CON-HS (P<0. 05). Western blot did not detect differences in adrenal AT(1) receptor cont ent. Therefore, insufficiently suppressed PRA and PAL in response to HS int ake by sensory denervation may contribute to increased salt sensitivity and account for effectiveness of spironolactone in lowering blood pressure in this model.