Cocaine affects the dynamics of cytoskeletal proteins via sigma(1) receptors

Authors
Citation
Tp. Su et T. Hayashi, Cocaine affects the dynamics of cytoskeletal proteins via sigma(1) receptors, TRENDS PHAR, 22(9), 2001, pp. 456-458
Citations number
23
Language
INGLESE
art.tipo
Editorial Material
Categorie Soggetti
Pharmacology & Toxicology
Volume
22
Issue
9
Year of publication
2001
Pages
456 - 458
Database
ISI
SICI code
Abstract
Cytoskeletal proteins are important in protein trafficking, membrane protei n clustering, dendrite growth and the morphological maintenance of neurons. Sigma, receptors are unique endoplasmic reticular (ER) proteins that bind (+)benzomorphans, neurosteroids and psychotropic drugs such as cocaine. Coc aine, via sigma, receptors, can cause the dissociation of a cytoskeletal ad aptor protein ankyrin from inositol (1,4,5)-trisphosphate [Ins(1,4,5)P-3] r eceptors on the ER as a sigma(1)-receptor-ankyrin complex, which then trans locates to the plasma membrane and nucleus. The dissociation of sigma(1)-re ceptor-ankyrin from Ins(1,4,5)P-3 receptors also increases the intracellula r Ca2+ concentration ([Ca2+], which affects the activity of cytoskeletal pr oteins. Furthermore, cocaine might increase [Ca2+](i) via phospholipase C ( PLC)-linked dopamine D1 receptors. We hypothesize that cocaine might cause life-long changes in neurons via cytoskeletal proteins by interacting with both D1 receptors and sigma, receptors.