The wound-healing effect of fibrin glue for tracheal anastomosis in experimental pulmonary surgery

Citation
M. Takagi et al., The wound-healing effect of fibrin glue for tracheal anastomosis in experimental pulmonary surgery, SURG TODAY, 31(9), 2001, pp. 845-847
Citations number
6
Language
INGLESE
art.tipo
Editorial Material
Categorie Soggetti
Surgery
Journal title
SURGERY TODAY
ISSN journal
0941-1291 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
845 - 847
Database
ISI
SICI code
0941-1291(2001)31:9<845:TWEOFG>2.0.ZU;2-8
Abstract
The leakage of tracheal anastomoses is one of the major complications that occurs after tracheal reconstruction. Improved reinforcing methods for anas tomoses would thus be clinically useful. To find a better technique, we exa mined the postoperative would-healing effect of fibrin glue on tracheal ana stomosis in the rat. Experimental rats were divided into two groups. In the control group (n = 21), the trachea was anastomosed by interrupted absorba ble sutures. In the fibrin glue group (n = 21), the trachea was anastomosed in the same manner as the control group, with the addition of fibrin glue around the area of anastomosis. In the two groups, we studied the amount of hydroxyproline and histological findings on the seventh, 14th, and 21st po stoperative day. The amount of hydroxyproline and collagen fibers in the fi brin glue group was more than in the control group on the seventh postopera tive day. These results suggest that fibrin glue has a promotive effect in the healing of tracheal anastomosis.