Melanin and blood concentration in human skin studied by multiple regression analysis: experiments

Citation
M. Shimada et al., Melanin and blood concentration in human skin studied by multiple regression analysis: experiments, PHYS MED BI, 46(9), 2001, pp. 2385-2395
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary
Journal title
PHYSICS IN MEDICINE AND BIOLOGY
ISSN journal
0031-9155 → ACNP
Volume
46
Issue
9
Year of publication
2001
Pages
2385 - 2395
Database
ISI
SICI code
0031-9155(200109)46:9<2385:MABCIH>2.0.ZU;2-9
Abstract
Knowledge of the mechanism of human skin colour and measurement of melanin and blood concentration in human skin are needed in the medical and cosmeti c fields. The absorbance spectrum from reflectance at the visible wavelengt h of human skin increases under several conditions such as a sunburn or sca lding. The change of the absorbance spectrum from reflectance including the scattering effect does not correspond to the molar absorption spectrum of melanin and blood. The modified Beer-Lambert law is applied to the change i n the absorbance spectrum from reflectance of human skin as the change in m elanin and blood is assumed to be small. The concentration of melanin and b lood was estimated from the absorbance spectrum reflectance of human skin u sing multiple regression analysis. Estimated concentrations were compared w ith the measured one in a phantom experiment and this method was applied to in vivo skin.