Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: Implications for autoimmunity and tumor immunity

Citation
S. Sakaguchi et al., Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: Implications for autoimmunity and tumor immunity, MICROBES IN, 3(11), 2001, pp. 911-918
Citations number
50
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
MICROBES AND INFECTION
ISSN journal
1286-4579 → ACNP
Volume
3
Issue
11
Year of publication
2001
Pages
911 - 918
Database
ISI
SICI code
1286-4579(200109)3:11<911:ISTMBT>2.0.ZU;2-0
Abstract
T-cell-mediated dominant control of self-reactive T cells is one mechanism for maintaining immunologic self tolerance. It also hampers the generation of immunity to autologous tumor cells. Abrogation of the control can evoke potent tumor immunity as well as autoimmunity in normal animals. This commo n regulatory mechanism for autoimmunity and tumor immunity can be exploited to devise a novel immunotherapy against cancer. (C) 2001 Editions scientif iques et medicales Elsevier SAS.