T-cell-mediated dominant control of self-reactive T cells is one mechanism
for maintaining immunologic self tolerance. It also hampers the generation
of immunity to autologous tumor cells. Abrogation of the control can evoke
potent tumor immunity as well as autoimmunity in normal animals. This commo
n regulatory mechanism for autoimmunity and tumor immunity can be exploited
to devise a novel immunotherapy against cancer. (C) 2001 Editions scientif
iques et medicales Elsevier SAS.